Low-Grade B Cell Lymphoproliferative Disorder Masquerading as Chronic Rhinosinusitis

A chronic B-cell lymphoproliferative disorder.

A 65-year-old male patient was admitted who had been suffering for some months from weakness and sensory alterations of the legs, with difficulty in walking. At physical examination pallor, hepatomegaly and splenomegaly (6 cm below the costal margin) were found; there was no lymphadenopathy. Laboratory findings showed anemia (Hb 8.3 g/dL), leucocytosis (WBC 42.3u10/L), normal platelet count (23...

[Senile EBV-associated B-cell lymphoproliferative disorder].

Epstein-Barrvirus (EBV)は1964年 にアフリカのバー キットリンパ腫培養細胞から発見された.そ の後,上 咽頭 がんや 胃がんなどとの関わ りも明らかにされ,歴 史的に最 も活発 に研究 がな されて きた ヒ トがん ウイルスhuman Cancer virusで あると言える.そ の明 らかな発癌 との関連 にも関わらず,EBVは 高度に普遍的なウイルスで もある. EBVは 主に唾液 を関した母子感染によって伝播 されると 考えられる.わ が国の25歳 以上の成人人口においては,ほ ぼ100%に 近い感染率を示す とされる. EBVと 血 液 リ ンパ 系 疾 患 との 関 わ りは 深 い.表1に, 主 なEBV関 連 血 液 リ ンパ 系 疾 患 を示 す.知 られ る 限 り リ ンパ 系 疾 患 が 主 体 で あ り,顆 粒 球 系 な ど他 ...

Rituximab therapy in a patient with low grade B-cell lymphoproliferative disease and concomitant acquired angioedema

Acquired angioedema is often associated with significant morbidity. An underlying lymphatic malignancy, autoimmune disorder, adenocarcinoma, or other malignancy may be present. Screening for these disorders should occur in all patients with acquired angioedema as treatment may result in resolution of angioedema.

Chronic Low-grade Inflammation after Exercise: Controversies

Small cell lung cancer mimicking high-grade lymphoma in a patient with concurrent B-cell lymphoproliferative disorder.

A 77-year-old woman with a remote smoking history presented with progressive dyspnea, chest discomfort, and hypoxia. Computed tomography showed extensive mediastinal, hilar, and perisplenic adenopathy. Her laboratory work was notable for thrombocytopenia (platelets 5 77 K/mL), mild anemia (hemoglobin 5 11.2 g/dL), high lactate dehydrogenase (4325 IU/L), and hyperuricemia (11.2 mg/dL). Because o...